Ser411
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Home > Phosphorylation Site Page: > Ser411  -  CDT1 (human)

Site Information
PAtPPAAsPsALkGV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 21440504

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
colorectal cancer ( 2 ) , colorectal carcinoma ( 2 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 2 ) , fibroblast ( 2 ) , HCT116 (intestinal) ( 2 ) , HeLa (cervical) ( 2 )

Upstream Regulation
Putative in vivo kinases:
JNK1 (human) ( 2 ) , P38A (human) ( 2 )
Kinases, in vitro:
P38A (human) ( 2 )
Treatments:
nocodazole ( 2 ) , SB203580 ( 2 ) , sorbitol ( 2 ) , UV ( 2 )

Downstream Regulation
Effects of modification on CDT1:
activity, inhibited ( 2 ) , molecular association, regulation ( 2 ) , protein stabilization ( 2 )
Inhibit interaction with:
RAMP (human) ( 2 )

References 

1

Zhou Y, et al. (2020) Distinct and sequential re-replication barriers ensure precise genome duplication. PLoS Genet 16, e1008988
32841231   Curated Info

2

Chandrasekaran S, Tan TX, Hall JR, Cook JG (2011) Stress-stimulated mitogen-activated protein kinases control the stability and activity of the cdt1 DNA replication licensing factor. Mol Cell Biol 31, 4405-16
21930785   Curated Info