Lys714
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Home > Ubiquitylation Site Page: > Lys714  -  MALT1 (human)

Site Information
VGkPLIAkLDMHRGL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2134707

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 2 )
Disease tissue studied:
leukemia ( 2 ) , T cell leukemia ( 2 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 2 ) , HEp-2 (squamous) ( 1 ) , Jurkat (T lymphocyte) ( 1 , 2 ) , T lymphocyte-lymph node ( 2 ) , T lymphocyte-spleen ( 2 )

Downstream Regulation
Effects of modification on MALT1:
molecular association, regulation ( 2 ) , protein degradation ( 2 )
Induce interaction with:
IKKA (human) ( 2 )

References 

1

Akimov V, et al. (2018) UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites. Nat Struct Mol Biol 25, 631-640
29967540   Curated Info

2

Oeckinghaus A, et al. (2007) Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation. EMBO J 26, 4634-45
17948050   Curated Info