Lys714

Site Information
VGkPLIAkLDMHRGL SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 2134707

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 ) , mutation of modification site ( 2 )
Disease tissue studied:	leukemia ( 2 ) , T cell leukemia ( 2 )
Relevant cell line - cell type - tissue:	HEK293T (epithelial) ( 2 ) , HEp-2 (squamous) ( 1 ) , Jurkat (T lymphocyte) ( 1 , 2 ) , T lymphocyte-lymph node ( 2 ) , T lymphocyte-spleen ( 2 )

Downstream Regulation
Effects of modification on MALT1:	molecular association, regulation ( 2 ) , protein degradation ( 2 )
Induce interaction with:	IKKA (human) ( 2 )

References
1	Akimov V, et al. (2018) UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites. Nat Struct Mol Biol 25, 631-640 29967540 Curated Info
2	Oeckinghaus A, et al. (2007) Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation. EMBO J 26, 4634-45 17948050 Curated Info