Tyr512
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Home > Phosphorylation Site Page: > Tyr512  -  CFTR (human)

Site Information
NIIFGVsyDEyRYRS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 21041602

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , BHK (fibroblast) ( 1 ) , BHK-21 (fibroblast) ( 2 ) , oocyte ( 1 )

Upstream Regulation
Putative in vivo kinases:
Syk (human) ( 1 , 2 )
Kinases, in vitro:
Syk (human) ( 1 , 2 )
Treatments:
574711 ( 1 ) , siRNA ( 2 )

Downstream Regulation
Effects of modification on CFTR:
intracellular localization ( 1 , 2 )
Effects of modification on biological processes:
endocytosis, induced ( 2 )

References 

1

Luz S, et al. (2011) Contribution of Casein Kinase 2 and Spleen Tyrosine Kinase to CFTR Trafficking and Protein Kinase A-Induced Activity. Mol Cell Biol 31, 4392-404
21930781   Curated Info

2

Mendes AI, et al. (2011) Antagonistic Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Cell Surface Expression by Protein Kinases WNK4 and Spleen Tyrosine Kinase. Mol Cell Biol 31, 4076-86
21807898   Curated Info

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