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Site Information |
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ASLGRRAsFHLECLK SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 455278 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
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Downstream Regulation | |
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Effects of modification on CACNA1C: | |
Induce interaction with: | |
Inhibit interaction with: |
References | |
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Martín-Aragón Baudel M, et al. (2022) Spatiotemporal Control of Vascular Ca1.2 by α1 S1928 Phosphorylation. Circ Res 131, 1018-1033
36345826 Curated Info |
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Patriarchi T, et al. (2016) Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor. EMBO J 35, 1330-45
27103070 Curated Info |
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Levin MD, et al. (2016) KATP channel gain-of-function leads to increased myocardial L-type Ca2+ current and contractility in Cantu syndrome. Proc Natl Acad Sci U S A 113, 6773-8
27247394 Curated Info |
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Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451 Curated Info |
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Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079 Curated Info |
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Yang L, et al. (2009) Protein kinase C isoforms differentially phosphorylate Ca(v)1.2 alpha(1c). Biochemistry 48, 6674-83
19527072 Curated Info |
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Lemke T, et al. (2008) Unchanged beta-adrenergic stimulation of cardiac L-type calcium channels in Ca v 1.2 phosphorylation site S1928A mutant mice. J Biol Chem 283, 34738-44
18829456 Curated Info |
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Hall DD, et al. (2007) Critical role of cAMP-dependent protein kinase anchoring to the L-type calcium channel Cav1.2 via A-kinase anchor protein 150 in neurons. Biochemistry 46, 1635-46
17279627 Curated Info |