Ser336
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Home > Phosphorylation Site Page: > Ser336  -  RIPK1 (mouse)

Site Information
LPPsRsNsEQPGSLH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 209632700

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 , 3 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
fibrosarcoma of soft tissue ( 3 )
Relevant cell line - cell type - tissue:
BV2 (microglia) ( 3 ) , HEK293T (epithelial) ( 1 ) , L929 (fibroblast) ( 3 ) , macrophage ( 1 ) , macrophage-bone marrow ( 2 ) , MEF (fibroblast) ( 1 , 2 , 3 )

Upstream Regulation
Putative in vivo kinases:
MAPKAPK2 (mouse) ( 1 , 2 )
Kinases, in vitro:
MAPKAPK2 (mouse) ( 1 )
Treatments:
bacterial infection ( 1 ) , PF3644022 ( 1 ) , SB203580 ( 1 ) , TNF ( 2 )

Downstream Regulation
Effects of modification on RIPK1:
enzymatic activity, induced ( 3 ) , molecular association, regulation ( 3 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 , 2 )
Induce interaction with:
RIPK3 (mouse) ( 3 )

References 

1

Menon MB, et al. (2017) p38(MAPK)/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection. Nat Cell Biol 19, 1248-1259
28920954   Curated Info

2

Dondelinger Y, et al. (2017) MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death. Nat Cell Biol 19, 1237-1247
28920952   Curated Info

3

Geng J, et al. (2017) Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis. Nat Commun 8, 359
28842570   Curated Info