Thr290
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Home > Phosphorylation Site Page: > Thr290  -  Cot (mouse)

Site Information
LPKDLRGtEIYMSPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455276

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
Cot (mouse) ( 1 )
Putative in vivo kinases:
IKKB (mouse) ( 2 )
Treatments:
LPS ( 1 , 2 ) , PS-1145 ( 2 ) , siRNA ( 2 ) , TNF ( 2 )

Downstream Regulation
Effects of modification on Cot:
enzymatic activity, induced ( 2 )

References 

1

Robinson MJ, et al. (2007) Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages. Mol Cell Biol 27, 7355-64
17709378   Curated Info

2

Cho J, Melnick M, Solidakis GP, Tsichlis PN (2005) Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals. J Biol Chem 280, 20442-8
15778223   Curated Info