Ser169

Site Information
PPAPAHAsPIRAPEV SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 20804974

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 , 3 , 4 , 5 )
Disease tissue studied:	neuroblastoma ( 5 )
Relevant cell line - cell type - tissue:	'brain, striatum' ( 3 ) , bEnd3 ( 3 ) , MEF (fibroblast) ( 4 ) , N1E-115 (neuron) ( 5 ) , stromal ( 2 )

Upstream Regulation
Treatments:	ischemia ( 2 ) , LPA ( 5 )

References
1	Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250 27841257 Curated Info
2	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
3	Namiki J, et al. (2012) Nestin protein is phosphorylated in adult neural stem/progenitor cells and not endothelial progenitor cells. Stem Cells Int 2012, 430138 23028390 Curated Info
4	Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6 21659605 Curated Info
5	Wang Y, et al. (2011) Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem 286, 18190-201 21454597 Curated Info