Tyr232
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Home > Phosphorylation Site Page: > Tyr232  -  FAS (human)

Site Information
sDVDLsKyItTIAGV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455221

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
liver cancer ( 2 )
Relevant cell line - cell type - tissue:
Huh7 (hepatic) ( 1 , 2 ) , MEF (fibroblast) [IGF1R (mouse)] ( 1 )

Upstream Regulation
Treatments:
Fas ( 2 ) , osmotic_stress ( 2 )

Downstream Regulation
Effects of modification on FAS:
intracellular localization ( 1 , 2 ) , molecular association, regulation ( 1 , 2 )
Effects of modification on biological processes:
apoptosis, altered ( 1 , 2 )
Induce interaction with:
CASP8 (human) ( 2 ) , FADD (human) ( 2 ) , FAS (human) ( 1 )

References 

1

Eberle A, et al. (2007) CD95 tyrosine phosphorylation is required for CD95 oligomerization. Apoptosis 12, 719-29
17195092   Curated Info

2

Eberle A, Reinehr R, Becker S, Häussinger D (2005) Fluorescence resonance energy transfer analysis of proapoptotic CD95-EGF receptor interactions in Huh7 cells. Hepatology 41, 315-26
15660394   Curated Info

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