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Site Information |
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sALNRtSsDsALHTs SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 454622 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
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Downstream Regulation | |
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Effects of modification on TORC2: | |
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Induce interaction with: |
References | |
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Kanki H, et al. (2020) CREB Coactivator CRTC2 Plays a Crucial Role in Endothelial Function. J Neurosci 40, 9533-9546
33127851 Curated Info |
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Patra KC, et al. (2018) Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. Nat Cell Biol 20, 811-822
29941929 Curated Info |
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Degryse S, et al. (2017) Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia. Leukemia 32
28852199 Curated Info |
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Hogan MF, et al. (2015) Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2. J Biol Chem 290, 25997-6006
26342077 Curated Info |
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Han J, et al. (2015) The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1. Nature 524, 243-6
26147081 Curated Info |
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Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356 Curated Info |
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Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079 Curated Info |
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Uebi T, et al. (2010) Phosphorylation of the CREB-specific coactivator TORC2 at Ser307 regulates its intracellular localization in COS-7 cells and in the mouse liver. Am J Physiol Endocrinol Metab 299, E413-25
20551288 Curated Info |
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Possemato A (2009) CST Curation Set: 8043; Year: 2011; Biosample/Treatment: tissue, liver/AICAR; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info |
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Possemato A (2009) CST Curation Set: 8042; Year: 2011; Biosample/Treatment: tissue, liver/AICAR; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
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Yoon YS, et al. (2009) Adiponectin and thiazolidinedione targets CRTC2 to regulate hepatic gluconeogenesis. Exp Mol Med 41, 577-83
19381067 Curated Info |
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Wang Y, Vera L, Fischer WH, Montminy M (2009) The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 460, 534-7
19543265 Curated Info |
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Ryu D, et al. (2009) TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1. Cell Metab 9, 240-51
19254569 Curated Info |
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Qi L, et al. (2009) Adipocyte CREB promotes insulin resistance in obesity. Cell Metab 9, 277-86
19254572 Curated Info |
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Horike N, et al. (2008) AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver. J Biol Chem 283, 33902-10
18801732 Curated Info |
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Jansson D, et al. (2008) Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2. Proc Natl Acad Sci U S A 105, 10161-6
18626018 Curated Info |
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Dentin R, et al. (2008) Hepatic glucose sensing via the CREB coactivator CRTC2. Science 319, 1402-5
18323454 Curated Info |
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Dentin R, et al. (2007) Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature 449, 366-9
17805301 Curated Info |
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Koo SH, et al. (2005) The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 437, 1109-11
16148943 Curated Info |
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Screaton RA, et al. (2004) The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell 119, 61-74
15454081 Curated Info |