Tyr153
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.9
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Tyr153  -  CASP9 (human)

Site Information
RGNADLAyILSMEPC   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455198

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 1 ) , HEK293T (epithelial) ( 1 ) , PT-67 ( 2 ) , U-937 (myeloid) ( 2 )

Upstream Regulation
Putative in vivo kinases:
Abl (human) ( 2 )
Kinases, in vitro:
Abl (human) ( 2 )

Downstream Regulation
Effects of modification on CASP9:
activity, induced ( 2 ) , enzymatic activity, inhibited ( 1 ) , molecular association, regulation ( 2 )
Effects of modification on biological processes:
apoptosis, induced ( 2 )
Induce interaction with:
p53 (human) ( 2 )

References 

1

Serrano BP, Szydlo HS, Alfandari D, Hardy JA (2017) Active site-adjacent phosphorylation at Tyr-397 by c-Abl kinase inactivates caspase-9. J Biol Chem 292, 21352-21365
29066624   Curated Info

2

Raina D, et al. (2005) c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. J Biol Chem 280, 11147-51
15657060   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2024 Cell Signaling Technology, Inc.