Tyr358
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Home > Phosphorylation Site Page: > Tyr358  -  HCRTR1 (human)

Site Information
SAANPIIyNFLSGKF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2063600

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:
CHO (fibroblast) ( 1 ) , HT-29 (intestinal) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 1 )
Putative upstream phosphatases:
SHP-2 (human) ( 1 )
Treatments:
orexin ( 1 ) , PP2 ( 1 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, induced ( 1 )

References 

1

Voisin T, et al. (2008) A hallmark of immunoreceptor, the tyrosine-based inhibitory motif ITIM, is present in the G protein-coupled receptor OX1R for orexins and drives apoptosis: a novel mechanism. FASEB J 22, 1993-2002
18198212   Curated Info

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