Tyr266
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Home > Phosphorylation Site Page: > Tyr266  -  TBX21 (human)

Site Information
VLQsLHKyQPRLHIV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 20583306

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , CD4+ (T lymphocyte) ( 1 ) , T lymphocyte ( 1 )

Upstream Regulation
Putative in vivo kinases:
Abl (human) ( 1 )
Kinases, in vitro:
Abl (human) ( 1 )

Downstream Regulation
Effects of modification on TBX21:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell differentiation, altered ( 1 ) , cell growth, induced ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
DNA ( 1 )

References 

1

Chen A, et al. (2011) c-Abl-Mediated Tyrosine Phosphorylation of the T-bet DNA-Binding Domain Regulates CD4+ T-Cell Differentiation and Allergic Lung Inflammation. Mol Cell Biol 31, 3445-56
21690296   Curated Info