Ser45
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.0.1
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser45  -  AP2M1 (rat)

Site Information
HARQQVRsPVTNIAR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2048345

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'brain, cerebellum' ( 2 ) , 'brain, cerebral cortex' ( 2 ) , 293 (epithelial) ( 1 ) , brain ( 1 ) , dorsal root ganglia ( 1 )

Upstream Regulation
Regulatory protein:
CDK5R1 (human) ( 1 )
Putative in vivo kinases:
CDK5 (rat) ( 1 )
Kinases, in vitro:
CDK5 (rat) ( 1 )
Treatments:
peptide inhibitor ( 1 ) , seliciclib ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on AP2M1:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 )
Inhibit interaction with:
TRPV1 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
hyperalgesia ( 1 )

References 

1

Liu J, Du J, Wang Y (2019) CDK5 inhibits the clathrin-dependent internalization of TRPV1 by phosphorylating the clathrin adaptor protein AP2μ2. Sci Signal 12
31186372   Curated Info

2

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2019 Cell Signaling Technology, Inc.