Tyr1162
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Home > Phosphorylation Site Page: > Tyr1162  -  HER4 (human)

Site Information
RDKPKQEyLNPVEEN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2045347

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 2 ) , immunoprecipitation ( 2 ) , mass spectrometry ( 3 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
melanoma skin cancer ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , 3T3 (fibroblast) ( 2 ) , COS7 (fibroblast) ( 1 ) , HEK293T (epithelial) ( 3 ) , SK-MEL-23 (melanocyte) ( 2 )

Upstream Regulation
Kinases, in vitro:
HER4 (human) ( 2 )
Treatments:
lapatinib ( 2 )

Downstream Regulation
Effects of modification on HER4:
enzymatic activity, induced ( 2 ) , molecular association, regulation ( 1 , 3 , 4 )
Effects of modification on biological processes:
apoptosis, inhibited ( 2 ) , cell growth, induced ( 2 ) , cell motility, induced ( 1 )
Induce interaction with:
Arg (human) ( 3 ) , GRB2 (human) ( 4 ) , VAV2 (human) ( 3 ) , VAV3 (human) ( 1 )

References 

1

Ojala VK, et al. (2020) The guanine nucleotide exchange factor VAV3 participates in ERBB4-mediated cancer cell migration. J Biol Chem
32561640   Curated Info

2

Prickett TD, et al. (2009) Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4. Nat Genet 41, 1127-32
19718025   Curated Info

3

Kaushansky A, et al. (2008) System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties. Chem Biol 15, 808-17
18721752   Curated Info

4

Schulze WX, Deng L, Mann M (2005) Phosphotyrosine interactome of the ErbB-receptor kinase family. Mol Syst Biol 1, 2005.0008
16729043   Curated Info

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