Ser69
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Home > Phosphorylation Site Page: > Ser69  -  14-3-3 sigma (human)

Site Information
LssIEQksNEEGsEE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454996

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
CK2A1 (human) ( 1 )
Treatments:
TGF-beta ( 1 )

Downstream Regulation
Effects of modification on 14-3-3 sigma:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 ) , signaling pathway regulation ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
DNA ( 1 ) , SMAD3 (human) ( 1 )
Inhibit interaction with:
p53 (human) ( 1 )

References 

1

Zakharchenko O, Cojoc M, Dubrovska A, Souchelnytskyi S (2013) A Role of TGFß1 Dependent 14-3-3σ Phosphorylation at Ser69 and Ser74 in the Regulation of Gene Transcription, Stemness and Radioresistance. PLoS One 8, e65163
23741479   Curated Info