Ser48
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Home > Phosphorylation Site Page: > Ser48  -  PPP1R3A (rabbit)

Site Information
PQPSRRGsESSEEVY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449320

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
'muscle, skeletal' ( 1 ) , L6 (myoblast) ( 2 )

Upstream Regulation
Putative in vivo kinases:
CAMK2A (mouse) ( 1 )
Kinases, in vitro:
CAMK2A (mouse) ( 1 ) , PKACA (mouse) ( 1 )
Treatments:
Ca(2+) ( 1 ) , cAMP_analog ( 2 ) , insulin ( 2 ) , KN-93 ( 1 )

Downstream Regulation
Effects of modification on PPP1R3A:
enzymatic activity, induced ( 2 )

References 

1

Sacchetto R, Bovo E, Donella-Deana A, Damiani E (2005) Glycogen- and PP1c-targeting subunit GM is phosphorylated at Ser48 by sarcoplasmic reticulum-bound Ca2+-calmodulin protein kinase in rabbit fast twitch skeletal muscle. J Biol Chem 280, 7147-55
15591318   Curated Info

2

Srinivasan M, Begum N (1994) Regulation of protein phosphatase 1 and 2A activities by insulin during myogenesis in rat skeletal muscle cells in culture. J Biol Chem 269, 12514-20
8175660   Curated Info