Lys538
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Home > Acetylation Site Page: > Lys538  -  BMAL1 (human)

Site Information
DASSPGGkKILNGGT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1968606

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , modification-specific antibody ( 2 ) , mutation of modification site ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
fibroblast-embryo ( 1 ) , MEF (fibroblast) ( 2 )

Downstream Regulation
Effects of modification on BMAL1:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
transcription, altered ( 2 ) , transcription, inhibited ( 1 )
Induce interaction with:
CRY1 (mouse) ( 1 )

References 

1

Patke A, et al. (2017) Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder. Cell 169, 203-215.e13
28388406   Curated Info

2

Grimaldi B, et al. (2007) Chromatin remodeling and circadian control: master regulator CLOCK is an enzyme. Cold Spring Harb Symp Quant Biol 72, 105-12
18419267   Curated Info