Lys544
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Home > Acetylation Site Page: > Lys544  -  BMAL1 (mouse)

Site Information
DASSPGGkKILNGGT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1968606

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 3 ) , modification-specific antibody ( 1 , 2 , 3 ) , mutation of modification site ( 3 ) , western blotting ( 1 , 3 )
Disease tissue studied:
gestational cancer ( 2 , 3 ) , gestational trophoblastic choriocarcinoma ( 2 , 3 )
Relevant cell line - cell type - tissue:
JEG-3 (uterine) ( 2 , 3 ) , liver ( 2 , 3 ) , MEF (fibroblast) ( 1 , 3 )

Upstream Regulation
Regulatory protein:
CRY1 (human) ( 3 ) , MTA1 (mouse) ( 1 ) , PER2 (human) ( 3 ) , SIRT2 (human) ( 2 ) , SIRT3 (human) ( 2 )
Treatments:
NAD_zwitterion ( 2 ) , nicotinamide ( 1 , 2 ) , siRNA ( 1 ) , trichostatin_A ( 2 )

Downstream Regulation
Effects of modification on BMAL1:
molecular association, regulation ( 3 ) , phosphorylation ( 2 ) , protein stabilization ( 2 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 ) , transcription, altered ( 3 ) , transcription, induced ( 2 ) , transcription, inhibited ( 1 )
Induce interaction with:
CRY1 (human) ( 3 )

References 

1

Li DQ, et al. (2013) Metastasis-associated protein 1 is an integral component of the circadian molecular machinery. Nat Commun 4, 2545
24089055   Curated Info

2

Nakahata Y, et al. (2008) The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 134, 329-40
18662547   Curated Info

3

Hirayama J, et al. (2007) CLOCK-mediated acetylation of BMAL1 controls circadian function. Nature 450, 1086-90
18075593   Curated Info

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