Thr74
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Home > Phosphorylation Site Page: > Thr74  -  CCNE1 (mouse)

Site Information
DPCSFIPtPNKEEDN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454411

In vivo Characterization
Methods used to characterize site in vivo:
microscopy-colocalization with upstream kinase ( 3 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 3 ) , western blotting ( 1 , 3 )
Disease tissue studied:
liver cancer ( 2 ) , squamous cell carcinoma of the liver ( 2 )
Relevant cell line - cell type - tissue:
'stem, hematopoietic' ( 2 ) , bone marrow ( 1 ) , erythroblast-spleen ( 2 ) , HSC (squamous) ( 2 ) , MEF (fibroblast) ( 3 ) , thymocyte-thymus ( 1 )

Downstream Regulation
Effects of modification on CCNE1:
activity, inhibited ( 3 ) , methylation ( 2 ) , phosphorylation ( 2 ) , protein degradation ( 1 , 2 , 3 ) , ubiquitination ( 1 , 2 )
Effects of modification on biological processes:
apoptosis, inhibited ( 2 ) , cell cycle regulation ( 1 , 2 , 3 ) , cell differentiation, altered ( 3 ) , cell differentiation, induced ( 2 ) , cell growth, altered ( 3 ) , DNA repair, altered ( 2 ) , transcription, altered ( 2 )

References 

1

Siu KT, et al. (2014) Chromosome instability underlies hematopoietic stem cell dysfunction and lymphoid neoplasia associated with impaired fbw7-mediated cyclin e regulation. Mol Cell Biol 34, 3244-58
24958101   Curated Info

2

Xu Y, et al. (2014) Fbw7-dependent cyclin E regulation ensures terminal maturation of bone marrow erythroid cells by restraining oxidative metabolism. Oncogene 33, 3161-71
23873023   Curated Info

3

Minella AC, et al. (2008) Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo. Genes Dev 22, 1677-89
18559482   Curated Info