Ser790

Site Information
PQPPSAIsPGENsKS SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 1883618704

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 )
Disease tissue studied:	breast cancer ( 1 ) , breast adenocarcinoma ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:	HEK293T (epithelial) ( 1 ) , MCF-7 (breast cell) ( 1 ) , MDA-MB-231 (breast cell) ( 1 ) , MDA-MB-468 (breast cell) ( 1 )

Downstream Regulation
Effects of modification on HIF2A:	molecular association, regulation ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:	carcinogenesis, induced ( 1 ) , cell motility, induced ( 1 )
Induce interaction with:	PIN1 (human) ( 1 )

References
1	Guillen-Quispe YN, et al. (2023) Oxygen-independent stabilization of HIF-2α in breast cancer through direct interaction with peptidyl-prolyl cis-trans isomerase NIMA-interacting 1. Free Radic Biol Med 207, 296-307 37473874 Curated Info