Lys383

Site Information
PAPkSNIkDLFVTTN SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 1883407600

In vivo Characterization
Methods used to characterize site in vivo:	flow cytometry ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:	leukemia ( 1 ) , acute erythroid leukemias, including erythroleukemia (M6a) and very rare pure erythroid leukemia (M6b) ( 1 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 ) , TF-1 (erythroid) ( 1 )

Downstream Regulation
Effects of modification on IL5RA:	protein degradation ( 1 )
Effects of modification on biological processes:	cell differentiation, inhibited ( 1 )

References
1	Zeng LW, et al. (2022) The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation. Cell Mol Immunol 19, 1117-1129 35982175 Curated Info