Lys404
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Home > Ubiquitylation Site Page: > Lys404  -  FBXW7 (human)

Site Information
GSDDNTLkVWSAVTG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1881459300

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on FBXW7:
molecular association, regulation ( 1 ) , protein degradation ( 1 )
Induce interaction with:
TRIP12 (human) ( 1 )

References 

1

Khan OM, et al. (2021) Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12. Nat Commun 12, 2043
33824312   Curated Info