Lys335
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Home > Acetylation Site Page: > Lys335  -  KLF5 (human)

Site Information
YAATIASkLAIHNPN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1880814002

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:
A549 (pulmonary) ( 1 )

Upstream Regulation
Treatments:
antibody ( 1 ) , C5aR_antagonist ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on KLF5:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
DNA ( 1 )

References 

1

Zhao C, et al. (2018) C5a induces A549 cell proliferation of non-small cell lung cancer via GDF15 gene activation mediated by GCN5-dependent KLF5 acetylation. Oncogene
29773900   Curated Info

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