Ser484
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Home > Phosphorylation Site Page: > Ser484  -  HIF2A (human)

Site Information
SSCSTPNsPEDYYTS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1876807202

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 ) , T387 (glioma) ( 1 )

Upstream Regulation
Putative in vivo kinases:
ERK1 (human) ( 1 ) , ERK2 (human) ( 1 )
Treatments:
LY3214996 ( 1 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on HIF2A:
molecular association, regulation ( 1 ) , protein stabilization ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
USP33 (human) ( 1 )

References 

1

Zhang A, et al. (2022) USP33 deubiquitinates and stabilizes HIF-2alpha to promote hypoxia response in glioma stem cells. EMBO J 41, e109187
35191554   Curated Info

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