Ser2439
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Home > Phosphorylation Site Page: > Ser2439  -  Notch 1 (human)

Site Information
SFLSGEPsQADVQPL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1875193400

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 )
Disease tissue studied:
cancer, squamous cell carcinoma ( 1 )
Relevant cell line - cell type - tissue:
HaCaT (keratinocyte) ( 1 ) , HeLa (cervical) ( 1 ) , SCC022 (squamous) ( 1 )

Upstream Regulation
Putative in vivo kinases:
PLK1 (human) ( 1 )
Kinases, in vitro:
PLK1 (human) ( 1 )
Treatments:
adriamycin ( 1 ) , arsenite ( 1 ) , BI2536 ( 1 ) , caffeine ( 1 ) , nocodazole ( 1 ) , Ro3280 ( 1 ) , ZM447439 ( 1 )

Downstream Regulation
Effects of modification on Notch 1:
protein degradation ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 )

References 

1

De Blasio C, et al. (2019) PLK1 targets NOTCH1 during DNA damage and mitotic progression. J Biol Chem
31597699   Curated Info