Thr207
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Home > Phosphorylation Site Page: > Thr207  -  Claudin-5 (mouse)

Site Information
YSAPRRPtANGDyDk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454390

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 ) , mutation of modification site ( 4 ) , phospho-antibody ( 1 , 4 )
Relevant cell line - cell type - tissue:
'brain, embryonic' ( 2 ) , bEnd3 ( 1 ) , brain ( 1 , 3 ) , COS (fibroblast) ( 1 ) , RLE (endothelial) ( 4 )

Upstream Regulation
Putative in vivo kinases:
GRK1 (human) ( 1 )
Kinases, in vitro:
GRK1 (human) ( 1 )
Treatments:
cAMP_analog ( 4 ) , LPA ( 1 ) , Y27632 ( 1 )

Downstream Regulation
Effects of modification on Claudin-5:
activity, induced ( 4 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 4 )

References 

1

Yamamoto M, et al. (2008) Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells. Am J Pathol 172, 521-33
18187566   Curated Info

2

Guo A (2007) CST Curation Set: 2717; Year: 2007; Biosample/Treatment: tissue, brain/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST](D/E)X(D/E)
Curated Info

3

Guo A (2007) CST Curation Set: 2718; Year: 2007; Biosample/Treatment: tissue, brain/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST](D/E)X(D/E)
Curated Info

4

Soma T, et al. (2004) Thr(207) of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP. Exp Cell Res 300, 202-12
15383327   Curated Info