Ser435
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Home > Phosphorylation Site Page: > Ser435  -  HIF2A (human)

Site Information
GKAILPPsQPWATEL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1874020200

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , mass spectrometry ( 1 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 ) , prostate cancer ( 1 )
Relevant cell line - cell type - tissue:
A549 (pulmonary) ( 1 ) , C4-2B (prostate cell) ( 1 ) , HCT116 (intestinal) ( 1 ) , HEK293T (epithelial) ( 1 ) , PC3 (prostate cell) ( 1 ) , RKO (intestinal) ( 1 ) , SW620 (intestinal) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Pim1 (human) ( 1 )
Treatments:
AZD1208 ( 1 ) , hypoxia ( 1 ) , PIM447 ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on HIF2A:
molecular association, regulation ( 1 ) , protein stabilization ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 ) , transcription, induced ( 1 )
Inhibit interaction with:
EGLN1 (human) ( 1 )

References 

1

Casillas AL, et al. (2021) Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors. Oncogene
34211090   Curated Info

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