Ser115
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Home > Phosphorylation Site Page: > Ser115  -  PIN1 (human)

Site Information
sQFSDCssAkARGDL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1873647702

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 )
Disease tissue studied:
liver cancer ( 1 ) , cholangiocellular carcinoma ( 1 ) , lung cancer ( 1 ) , small-cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:
HuCCT1 (hepatic) ( 1 ) , liver ( 1 ) , NCI-H69 (pulmonary) ( 1 ) , SG231 (hepatic) ( 1 )

Upstream Regulation
Putative in vivo kinases:
JNK1 (human) ( 1 ) , JNK2 (human) ( 1 )
Kinases, in vitro:
JNK1 (human) ( 1 )
Treatments:
retinoic_acid ( 1 ) , siRNA ( 1 ) , SP600125 ( 1 )

Downstream Regulation
Effects of modification on PIN1:
protein stabilization ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 ) , transcription, induced ( 1 )

References 

1

Lepore A, et al. (2021) Phosphorylation and stabilization of PIN1 by JNK promote intrahepatic cholangiocarcinoma growth. Hepatology
34048060   Curated Info

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