Lys577
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Home > Sumoylation Site Page: > Lys577  -  Nur77 (human)

Site Information
LQRIFYLkLEDLVPP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1873041100

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
leukemia ( 1 ) , acute myelogenous leukemia ( 1 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 1 ) , THP1 (myeloid) ( 1 )

Upstream Regulation
Regulatory protein:
SENP1 (human) ( 1 )
Treatments:
phorbol_ester ( 1 )

Downstream Regulation
Effects of modification on Nur77:
protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )

References 

1

Zhang L, et al. (2017) SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death. Cell Death Differ 24, 1530-1539
28622293   Curated Info

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