Lys169
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Home > Sumoylation Site Page: > Lys169  -  Pim1 (human)

Site Information
GVLHRDIkDENILID   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1873037706

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
leukemia ( 1 ) , chronic myelogenous leukemia ( 1 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on Pim1:
enzymatic activity, induced ( 1 ) , protein degradation ( 1 ) , ubiquitination ( 1 )

References 

1

Iyer RS, Chatham L, Sleigh R, Meek DW (2017) A functional SUMO-motif in the active site of PIM1 promotes its degradation via RNF4, and stimulates protein kinase activity. Sci Rep 7, 3598
28620180   Curated Info