Lys21
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Home > Ubiquitylation Site Page: > Lys21  -  GRK2 (human)

Site Information
LMAMEkSkATPAARA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1872283502

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 ) , breast adenocarcinoma ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , MCF-7 (breast cell) ( 1 ) , MCF10A1 (epithelial) ( 1 ) , MDA-MB-468 (breast cell) ( 1 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Regulatory protein:
ARRB2 (human) ( 1 )
Treatments:
isoproterenol ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on GRK2:
protein degradation ( 1 )

References 

1

Salcedo A, Mayor F, Penela P (2006) Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2. EMBO J 25, 4752-62
17006543   Curated Info

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