Ser71
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Home > Phosphorylation Site Page: > Ser71  -  PIN1 (human)

Site Information
HsQSRRPssWRQEKI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 18710000

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , immunoassay ( 4 ) , immunoprecipitation ( 1 , 2 , 3 , 4 ) , mass spectrometry ( 4 ) , mutation of modification site ( 1 , 3 , 4 ) , phospho-antibody ( 1 , 2 , 4 ) , western blotting ( 1 , 2 , 4 )
Disease tissue studied:
breast cancer ( 2 , 4 ) , breast ductal carcinoma ( 4 ) , breast cancer, triple negative ( 4 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 ) , lymphoma ( 2 ) , anaplastic large cell lymphoma ( 2 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 4 ) , A549 (pulmonary) ( 1 ) , breast ( 4 ) , HCC1937 (breast cell) ( 4 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 4 ) , HMLE (breast cell) ( 4 ) , MCF-10A (breast cell) ( 2 ) , MCF-7 (breast cell) ( 4 ) , MCF10A1 (epithelial) ( 4 ) , MDA-MB-231 (breast cell) ( 2 ) , MEF (fibroblast) ( 4 ) , oocyte ( 3 ) , SKBr3 (breast cell) ( 2 )

Upstream Regulation
Putative in vivo kinases:
DAPK1 (human) ( 1 , 4 )
Kinases, in vitro:
DAPK1 (human) ( 4 ) , PKACA (human) ( 4 )
Treatments:
H-89 ( 4 ) , NKH_477 ( 4 ) , progesterone ( 3 ) , retinoic_acid ( 2 ) , siRNA ( 4 ) , UV ( 1 )

Downstream Regulation
Effects of modification on PIN1:
activity, inhibited ( 3 ) , enzymatic activity, inhibited ( 1 , 4 ) , intracellular localization ( 4 ) , molecular association, regulation ( 3 ) , protein degradation ( 4 ) , ubiquitination ( 3 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 4 ) , cell cycle regulation ( 3 , 4 ) , cell motility, inhibited ( 4 ) , transcription, inhibited ( 4 )
Induce interaction with:
CPEB (human) ( 3 )

References 

1

Hilton BA, et al. (2015) ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1. Mol Cell 60, 35-46
26387736   Curated Info

2

Wei S, et al. (2015) Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer. Nat Med 21, 457-66
25849135   Curated Info

3

Nechama M, Lin CL, Richter JD (2013) An unusual two-step control of CPEB destruction by Pin1. Mol Cell Biol 33, 48-58
23090969   Curated Info

4

Lee TH, et al. (2011) Death-associated protein kinase 1 phosphorylates pin1 and inhibits its prolyl isomerase activity and cellular function. Mol Cell 42, 147-59
21497122   Curated Info

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