Lys539
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Home > Ubiquitylation Site Page: > Lys539  -  Nur77 (mouse)

Site Information
NRIASCLkEHMATVA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1869841400

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:
breast ( 1 ) , HEK293T (epithelial) ( 2 ) , HeLa (cervical) ( 2 ) , MCF-7 (breast cell) ( 1 )

Upstream Regulation
Treatments:
siRNA ( 2 ) , TNF ( 2 )

Downstream Regulation
Effects of modification on Nur77:
protein degradation ( 1 , 2 )

References 

1

Yang PB, et al. (2020) Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression. Proc Natl Acad Sci U S A 117, 27412-27422
33087562   Curated Info

2

Huang B, Pei HZ, Chang HW, Baek SH (2018) The E3 ubiquitin ligase Trim13 regulates Nur77 stability via casein kinase 2α. Sci Rep 8, 13895
30224829   Curated Info

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