Tyr376
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Home > Phosphorylation Site Page: > Tyr376  -  MLKL (human)

Site Information
DRVkstAyLSPQELE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1868624704

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , fibrosarcoma of soft tissue ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AXL (human) ( 1 ) , Mer (human) ( 1 ) , Tyro3 (human) ( 1 )
Kinases, in vitro:
Tyro3 (human) ( 1 )
Treatments:
BMS-777607 ( 1 ) , LDC1267 ( 1 ) , NSA ( 1 ) , SM-164 ( 1 ) , TNF ( 1 ) , Z-VAD-FMK ( 1 )

Downstream Regulation
Effects of modification on MLKL:
molecular association, regulation ( 1 ) , protein stabilization ( 1 )
Induce interaction with:
MLKL (human) ( 1 )

References 

1

Najafov A, et al. (2019) TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL. Mol Cell
31230815   Curated Info