Tyr80
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Home > Phosphorylation Site Page: > Tyr80  -  SOCS1 (human)

Site Information
LLDACGFyWGPLSVH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1868450203

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 ) , B cell lymphoma ( 1 ) , Hodgkin's lymphoma ( 1 )
Relevant cell line - cell type - tissue:
B lymphocyte ( 1 ) , IMR-90 (fibroblast) ( 1 ) , MEF (fibroblast) ( 1 ) , U2OS (bone cell) ( 1 )

Upstream Regulation
Regulatory protein:
EGF (human) ( 1 )
Kinases, in vitro:
BLK (human) ( 1 ) , LYN (human) ( 1 ) , Src (human) ( 1 ) , Yes (human) ( 1 )
Treatments:
dasatinib ( 1 ) , saracatinib ( 1 )

Downstream Regulation
Effects of modification on SOCS1:
activity, inhibited ( 1 ) , intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , signaling pathway regulation ( 1 )
Induce interaction with:
SOCS1 (human) ( 1 )
Inhibit interaction with:
p53 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
lymphoma ( 1 )

References 

1

Saint-Germain E, et al. (2019) Phosphorylation of SOCS1 Inhibits the SOCS1-p53 Tumor Suppressor Axis. Cancer Res 79, 3306-3319
31101761   Curated Info

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