Thr284
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Home > Phosphorylation Site Page: > Thr284  -  p53 (human)

Site Information
CPGRDRRtEEENLrk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 18675300

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AurB (human) ( 1 )
Kinases, in vitro:
AurB (human) ( 1 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, altered ( 1 ) , transcription, inhibited ( 1 )

References 

1

Wu L, Ma CA, Zhao Y, Jain A (2011) Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. J Biol Chem 286, 2236-44
20959462   Curated Info