Ser555

Site Information
RYRRRtQssGQDGRP SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 1855423

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:	breast cancer ( 1 )
Relevant cell line - cell type - tissue:	CHO-K1 (fibroblast) ( 1 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 2 ) , MDA-MB-231 (breast cell) ( 1 )

Downstream Regulation
Effects of modification on PIP5K1C:	intracellular localization ( 1 ) , molecular association, regulation ( 2 ) , protein degradation ( 1 )
Effects of modification on biological processes:	cell adhesion, induced ( 1 ) , cell motility, induced ( 1 , 2 ) , cytoskeletal reorganization ( 2 )
Inhibit interaction with:	talin 1 (human) ( 2 )

References
1	Jafari N, et al. (2016) p70S6K1 (S6K1)-mediated Phosphorylation Regulates Phosphatidylinositol 4-Phosphate 5-Kinase Type I γ Degradation and Cell Invasion. J Biol Chem 291, 25729-25741 27780861 Curated Info
2	Le OT, et al. (2015) Phosphorylation of phosphatidylinositol 4-phosphate 5-kinase γ by Akt regulates its interaction with talin and focal adhesion dynamics. Biochim Biophys Acta 1853, 2432-43 26149501 Curated Info