Lys47
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Home > Acetylation Site Page: > Lys47  -  EIF5A2 (human)

Site Information
IVEMsTskTGKHGHA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 18546316

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mass spectrometry ( 1 , 2 , 5 ) , modification-specific antibody ( 3 ) , mutation of modification site ( 3 ) , western blotting ( 3 )
Disease tissue studied:
colorectal cancer ( 3 ) , colorectal carcinoma ( 3 )
Relevant cell line - cell type - tissue:
A549 (pulmonary) ( 5 ) , HEK293T (epithelial) ( 3 ) , HeLa (cervical) ( 1 , 3 ) , Jurkat (T lymphocyte) ( 2 , 5 ) , SW480 (intestinal) ( 3 )

Upstream Regulation
Treatments:
MS275 ( 5 )

Downstream Regulation
Effects of modification on EIF5A2:
intracellular localization ( 3 )

References 

1

Weinert BT, et al. (2013) Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Rep 4, 842-51
23954790   Curated Info

2

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

3

Ishfaq M, et al. (2012) The role of acetylation in the subcellular localization of an oncogenic isoform of translation factor eIF5A. Biosci Biotechnol Biochem 76, 2165-7
23132580   Curated Info

4

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

5

Choudhary C, et al. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325, 834-40
19608861   Curated Info

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