Ser551

Site Information
ELQAPVRsPITRSFA SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 454074

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 , 3 , 4 , 5 , 7 )
Disease tissue studied:	breast cancer ( 5 ) , breast ductal carcinoma ( 5 ) , HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, triple negative ( 2 , 5 )
Relevant cell line - cell type - tissue:	breast ( 2 , 5 ) , HEK293T (epithelial) ( 3 ) , HeLa (cervical) ( 4 )

Upstream Regulation
Treatments:	ischemia ( 5 )

References
1	Bongartz H, et al. (2024) Dysregulated Gab1 signalling in triple negative breast cancer. Cell Commun Signal 22, 161 38448989 Curated Info
2	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
3	Franchin C, et al. (2015) Quantitative analysis of a phosphoproteome readily altered by the protein kinase CK2 inhibitor quinalizarin in HEK-293T cells. Biochim Biophys Acta 1854, 609-23 25278378 Curated Info
4	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
5	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
6	Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25 22424773 Curated Info
7	Chan PC, Sudhakar JN, Lai CC, Chen HC (2010) Differential phosphorylation of the docking protein Gab1 by c-Src and the hepatocyte growth factor receptor regulates different aspects of cell functions. Oncogene 29, 698-710 19881549 Curated Info