Ser347
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Home > Phosphorylation Site Page: > Ser347  -  NRF2 (mouse)

Site Information
NTsPSRAsPEHsVES   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 18258502

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 2 ) , mass spectrometry ( 1 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 2 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 , 2 , 3 )

Upstream Regulation
Putative in vivo kinases:
GSK3B (mouse) ( 3 )
Kinases, in vitro:
GSK3B (mouse) ( 3 )
Treatments:
siRNA ( 3 )

Downstream Regulation
Effects of modification on NRF2:
molecular association, regulation ( 3 ) , protein degradation ( 3 )
Induce interaction with:
BTRC (mouse) ( 3 )

References 

1

Rojo AI, et al. (2014) The PTEN/NRF2 axis promotes human carcinogenesis. Antioxid Redox Signal 21, 2498-514
24892215   Curated Info

2

Rada P, et al. (2012) Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis. Mol Cell Biol 32, 3486-99
22751928   Curated Info

3

Rada P, et al. (2011) SCF/{beta}-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner. Mol Cell Biol 31, 1121-33
21245377   Curated Info

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