Ser375
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Home > Phosphorylation Site Page: > Ser375  -  p53 (mouse)

Site Information
TkkGQsTsRHkkTMV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447534

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 3 ) , mass spectrometry (in vitro) ( 3 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 3 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 3 ) , MEF (fibroblast) ( 1 ) , SF9 ( 2 , 3 )

Downstream Regulation
Effects of modification on p53:
acetylation ( 2 )

References 

1

Lee MK, Sabapathy K (2007) Phosphorylation at carboxyl-terminal S373 and S375 residues and 14-3-3 binding are not required for mouse p53 function. Neoplasia 9, 690-8
17898864   Curated Info

2

Warnock LJ, Raines SA, Mee TR, Milner J (2005) Role of phosphorylation in p53 acetylation and PAb421 epitope recognition in baculoviral and mammalian expressed proteins. FEBS J 272, 1669-75
15794754   Curated Info

3

Otvos L, et al. (1998) A monoclonal antibody to a multiphosphorylated, conformational epitope at the carboxy-terminus of p53. Biochim Biophys Acta 1404, 457-74
9739174   Curated Info