Ser227
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.1.1
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser227  -  FBXW7 (human)

Site Information
QQRRRITsVQPPTGL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 17792400

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 2 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Akt1 (human) ( 1 ) , SGK1 (human) ( 2 )
Kinases, in vitro:
SGK1 (human) ( 2 )
Treatments:
dactolisib ( 1 ) , LY290024 ( 1 )

Downstream Regulation
Effects of modification on FBXW7:
protein degradation ( 1 ) , protein stabilization ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 1 ) , transcription, altered ( 1 )

References 

1

Schülein C, Eilers M, Popov N (2011) PI3K-dependent phosphorylation of Fbw7 modulates substrate degradation and activity. FEBS Lett 585, 2151-7
21620836   Curated Info

2

Mo JS, et al. (2011) Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase. J Cell Sci 124, 100-12
21147854   Curated Info