Tyr74
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Home > Phosphorylation Site Page: > Tyr74  -  Myc (human)

Site Information
sGLCsPSyVAVtPFs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 17553985

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
bone cancer ( 1 ) , Ewing's sarcoma ( 1 ) , leukemia ( 2 ) , acute myelogenous leukemia ( 2 ) , chronic myelogenous leukemia ( 2 ) , ovarian cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Abl (human) ( 2 )

Downstream Regulation
Effects of modification on Myc:
intracellular localization ( 2 )
Effects of modification on biological processes:
cell growth, induced ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
ovarian cancer ( 2 )

References 

1

Mei Z, et al. (2015) FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity. J Biol Chem 290, 16202-14
25944903   Curated Info

2

Sanchez-Arévalo Lobo VJ, et al. (2013) Dual regulation of Myc by Abl. Oncogene 32, 5261-71
23318434   Curated Info