Ser173
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Home > Phosphorylation Site Page: > Ser173  -  SMPD3 (mouse)

Site Information
QIKIyIDsPtNTsIS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 17547983

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 )
Disease tissue studied:
lung cancer ( 1 )
Relevant cell line - cell type - tissue:
A549 (pulmonary) ( 1 ) , brain ( 2 ) , HBE (epithelial) ( 1 )

Upstream Regulation
Treatments:
H2O2 ( 1 )

Downstream Regulation
Effects of modification on SMPD3:
enzymatic activity, induced ( 1 )

References 

1

Filosto S, et al. (2012) Neutral sphingomyelinase 2 activity and protein stability are modulated by phosphorylation of five conserved serines. J Biol Chem 287, 514-22
22074919   Curated Info

2

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info