Ser208
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Home > Phosphorylation Site Page: > Ser208  -  SMPD3 (mouse)

Site Information
GsIKRTAsVEYKGDG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 17547980

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 2 , 3 ) , mutation of modification site ( 2 )
Disease tissue studied:
lung cancer ( 2 )
Relevant cell line - cell type - tissue:
A549 (pulmonary) ( 2 ) , HBE (epithelial) ( 2 ) , lung ( 3 )

Upstream Regulation
Treatments:
H2O2 ( 2 )

Downstream Regulation
Effects of modification on SMPD3:
protein stabilization ( 2 )

References 

1

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

2

Filosto S, et al. (2012) Neutral sphingomyelinase 2 activity and protein stability are modulated by phosphorylation of five conserved serines. J Biol Chem 287, 514-22
22074919   Curated Info

3

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info