Ser161

Site Information
GWQEGSSsPRSHLsP SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 453810

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 4 , 5 , 6 , 7 )
Disease tissue studied:	lung cancer ( 2 ) , non-small cell lung cancer ( 2 )
Relevant cell line - cell type - tissue:	A549 (pulmonary) ( 1 ) , H2077 (pulmonary) ( 2 ) , H322M (pulmonary) ( 2 ) , HCC1359 (pulmonary) ( 2 ) , HCC366 (pulmonary) ( 2 ) , HCC4006 (pulmonary) ( 2 ) , HCC78 (pulmonary) ( 2 ) , HeLa (cervical) ( 4 , 5 , 7 ) , HOP62 (pulmonary) ( 2 ) , Jurkat (T lymphocyte) ( 6 ) , NCI-H1395 (pulmonary) ( 2 ) , NCI-H2030 (pulmonary) ( 2 ) , NCI-H322 (pulmonary) ( 2 ) , NCI-H520 (squamous) ( 2 ) , PC9 (pulmonary) ( 2 )

References
1	Kim JY, et al. (2013) Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells. Proc Natl Acad Sci U S A 110, 12414-9 23836654 Curated Info
2	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
3	Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25 22424773 Curated Info
4	Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5 21712546 Curated Info
5	Chen Y, et al. (2009) Combined integrin phosphoproteomic analyses and small interfering RNA--based functional screening identify key regulators for cancer cell adhesion and migration. Cancer Res 69, 3713-20 19351860 Curated Info
6	Mayya V, et al. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal 2, ra46 19690332 Curated Info
7	Beausoleil SA, et al. (2004) Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A 101, 12130-5 15302935 Curated Info