Ser18
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Home > Phosphorylation Site Page: > Ser18  -  FBXW7 (human)

Site Information
KRRRTGGsLRGNPSs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 17337001

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 1 , 2 ) , oocyte ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKCA (human) ( 2 ) , PKCI (human) ( 2 )
Kinases, in vitro:
PKCA (human) ( 1 ) , PKCE (mouse) ( 2 )
Treatments:
calyculin_A ( 2 ) , Go_6983 ( 2 )

Downstream Regulation
Effects of modification on FBXW7:
molecular association, regulation ( 1 ) , protein conformation ( 1 ) , ubiquitination ( 1 )
Inhibit interaction with:
CCNE1 (human) ( 1 )

References 

1

Zitouni S, et al. (2017) The stability of Fbw7α in M-phase requires its phosphorylation by PKC. PLoS One 12, e0183500
28850619   Curated Info

2

Durgan J, Parker PJ (2010) Regulation of the tumour suppressor Fbw7α by PKC-dependent phosphorylation and cancer-associated mutations. Biochem J 432, 77-87
20815813   Curated Info