Ser10
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Home > Phosphorylation Site Page: > Ser10  -  FBXW7 (human)

Site Information
QELLSVGsKRRRTGG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 17337000

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PKCA (human) ( 1 ) , PKCI (human) ( 1 )
Kinases, in vitro:
PKCE (mouse) ( 1 )
Treatments:
calyculin_A ( 1 ) , Go_6983 ( 1 )

Downstream Regulation
Effects of modification on FBXW7:
intracellular localization ( 1 )

References 

1

Durgan J, Parker PJ (2010) Regulation of the tumour suppressor Fbw7α by PKC-dependent phosphorylation and cancer-associated mutations. Biochem J 432, 77-87
20815813   Curated Info