Ser949
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Home > Phosphorylation Site Page: > Ser949  -  PAM (rat)

Site Information
DRVstEGsDQEKDED   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 453092

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , mass spectrometry ( 1 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 3 )
Disease tissue studied:
pituitary cancer ( 2 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 1 ) , 'brain, cerebellum' ( 1 ) , 'brain, cerebral cortex' ( 1 ) , AtT20 (pituitary cell) ( 2 , 3 ) , heart ( 1 )

Upstream Regulation
Putative in vivo kinases:
KIS (rat) ( 4 )
Kinases, in vitro:
CK2A1 (rat) ( 3 ) , KIS (rat) ( 4 )

Downstream Regulation
Effects of modification on PAM:
enzymatic activity, induced ( 3 ) , intracellular localization ( 2 , 3 )

References 

1

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

2

B├Ąck N, Rajagopal C, Mains RE, Eipper BA (2010) Secretory granule membrane protein recycles through multivesicular bodies. Traffic 11, 972-86
20374556   Curated Info

3

Steveson TC, et al. (2001) Access of a membrane protein to secretory granules is facilitated by phosphorylation. J Biol Chem 276, 40326-37
11524414   Curated Info

4

Caldwell BD, et al. (1999) The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha-amidating monooxygenase. J Biol Chem 274, 34646-56
10574929   Curated Info