Ser443

Site Information
PAtAPGtsPRANGLs SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 452915

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 4 , 5 , 6 , 8 , 9 , 10 )
Disease tissue studied:	breast cancer ( 5 ) , cervical cancer ( 9 ) , cervical adenocarcinoma ( 9 ) , leukemia ( 8 ) , acute myelogenous leukemia ( 8 ) , lung cancer ( 2 , 5 ) , non-small cell lung cancer ( 5 ) , non-small cell lung adenocarcinoma ( 2 ) , melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:	BT-549 (breast cell) ( 5 ) , endothelial-aorta ( 6 ) , H2077 (pulmonary) ( 5 ) , H322M (pulmonary) ( 5 ) , HCC366 (pulmonary) ( 5 ) , HCC78 (pulmonary) ( 5 ) , HeLa (cervical) ( 4 , 10 ) , HeLa S3 (cervical) ( 9 ) , HOP62 (pulmonary) ( 5 ) , K562 (erythroid) ( 4 ) , KG-1 (myeloid) ( 8 ) , lung ( 2 ) , MDA-MB-231 (breast cell) ( 5 ) , NCI-H157 (pulmonary) ( 5 ) , NCI-H1666 (pulmonary) ( 5 ) , NCI-H322 (pulmonary) ( 5 ) , WM239A (melanocyte) ( 1 )

Upstream Regulation
Treatments:	nocodazole ( 9 )

References
1	Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615 25850435 Curated Info
2	Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96 23911959 Curated Info
3	Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21 23312004 Curated Info
4	Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71 23186163 Curated Info
5	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
6	Verano-Braga T, et al. (2012) Time-resolved quantitative phosphoproteomics: new insights into Angiotensin-(1-7) signaling networks in human endothelial cells. J Proteome Res 11, 3370-81 22497526 Curated Info
7	Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25 22424773 Curated Info
8	Weber C, Schreiber TB, Daub H (2012) Dual phosphoproteomics and chemical proteomics analysis of erlotinib and gefitinib interference in acute myeloid leukemia cells. J Proteomics 75, 1343-56 22115753 Curated Info
9	Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3 20068231 Curated Info
10	Beausoleil SA, et al. (2006) A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol 24, 1285-92 16964243 Curated Info